Mehrdad Roghani Selected Research

Diosgenin

10/2021	Diosgenin ameliorates cellular and molecular changes in multiple sclerosis in C57BL/6 mice.
1/2021	Diosgenin Attenuates Cognitive Impairment in Streptozotocin-Induced Diabetic Rats: Underlying Mechanisms.
9/2020	Protective effect of diosgenin on LPS/D-Gal-induced acute liver failure in C57BL/6 mice.
5/2019	Diosgenin ameliorates testicular damage in streptozotocin-diabetic rats through attenuation of apoptosis, oxidative stress, and inflammation.
2/2017	Diosgenin ameliorates development of neuropathic pain in diabetic rats: Involvement of oxidative stress and inflammation.
12/2015	Diosgenin Mitigates Streptozotocin Diabetes-induced Vascular Dysfunction of the Rat Aorta: The Involved Mechanisms.

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Mehrdad Roghani Research Topics

Disease

36	Inflammation (Inflammations) 10/2022 - 10/2007
22	Neuroinflammatory Diseases 08/2022 - 05/2011
17	Alzheimer Disease (Alzheimer's Disease) 02/2022 - 10/2007
17	Gliosis 02/2022 - 01/2012
14	Cognitive Dysfunction 08/2022 - 01/2006
14	Memory Disorders (Memory Loss) 12/2020 - 03/2011
11	Temporal Lobe Epilepsy 10/2022 - 01/2013
11	Parkinson Disease (Parkinson's Disease) 01/2022 - 12/2004
11	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 07/2010
9	Seizures (Absence Seizure) 06/2022 - 01/2013
9	Epilepsy (Aura) 02/2021 - 01/2012
6	Status Epilepticus (Complex Partial Status Epilepticus) 10/2022 - 01/2013
5	Demyelinating Diseases (Demyelinating Disease) 04/2022 - 01/2018
5	Body Weight (Weight, Body) 11/2020 - 10/2018
4	Multiple Sclerosis 10/2021 - 05/2011
4	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 10/2021 - 01/2018
4	Hyperalgesia 02/2017 - 01/2010
3	Nervous System Diseases (Neurological Disorders) 10/2022 - 10/2015
3	Acute Kidney Injury (Acute Renal Failure) 09/2022 - 10/2018
3	Acute Liver Failure (Fulminant Hepatic Failure) 06/2022 - 09/2020
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2021 - 11/2020
2	Mitochondrial Diseases (Mitochondrial Disease) 09/2022 - 02/2022
2	Sepsis (Septicemia) 09/2022 - 10/2018
2	Dementia (Dementias) 01/2022 - 06/2013
2	Neuroblastoma 01/2021 - 12/2020
2	hypoglycemic encephalopathy 11/2020 - 11/2020
2	Pain (Aches) 12/2019 - 02/2017

Drug/Important Bio-Agent (IBA)

19	AntioxidantsIBA 09/2022 - 10/2007
14	Kainic Acid (Kainate)IBA 10/2022 - 01/2013
13	Streptozocin (Streptozotocin)FDA Link 02/2022 - 01/2006
11	Amyloid (Amyloid Fibrils)IBA 01/2022 - 03/2011
11	Oxidopamine (6 Hydroxydopamine)IBA 01/2021 - 07/2010
10	LipopolysaccharidesIBA 09/2022 - 01/2018
9	NF-kappa B (NF-kB)IBA 10/2022 - 05/2016
8	Neuroprotective AgentsIBA 10/2022 - 08/2010
7	Malondialdehyde (Propanedial)IBA 10/2022 - 08/2010
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2022 - 12/2016
6	Anticonvulsants (Antiepileptic Drugs)IBA 10/2022 - 11/2013
6	Glial Fibrillary Acidic ProteinIBA 10/2022 - 05/2016
6	Caspase 1 (ICE Protease)IBA 10/2022 - 04/2019
6	DiosgeninIBA 10/2021 - 12/2015
5	Amyloid beta-PeptidesIBA 12/2020 - 10/2007
5	GenisteinIBA 01/2018 - 07/2008
5	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 01/2012 - 10/2007
4	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2022 - 04/2017
4	Toll-Like Receptor 4IBA 10/2022 - 01/2017
4	paeonolIBA 10/2022 - 01/2021
4	Sirtuin 1IBA 06/2022 - 08/2018
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2021 - 05/2011
4	Interleukin-6 (Interleukin 6)IBA 01/2021 - 01/2019
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 10/2018
4	Cholinesterases (Cholinesterase)IBA 01/2021 - 10/2016
4	S-allylcysteine (allyl cysteine)IBA 05/2020 - 01/2017
4	Formaldehyde (Formol)FDA Link 12/2019 - 01/2010
4	AcetylcholinesteraseIBA 04/2019 - 01/2017
4	BerberineIBA 01/2019 - 01/2014
4	pelargonidinIBA 10/2016 - 01/2010
4	TeaIBA 01/2012 - 08/2009
3	Heme Oxygenase-1IBA 10/2022 - 12/2016
3	sinomenineIBA 08/2022 - 10/2020
3	Pharmaceutical PreparationsIBA 02/2022 - 01/2019
3	FlavonoidsIBA 01/2022 - 05/2016
3	InflammasomesIBA 02/2021 - 01/2021
3	CytokinesIBA 01/2021 - 09/2019
3	Cholinergic Agents (Cholinergics)IBA 01/2021 - 10/2016
3	Ellagic AcidIBA 01/2021 - 01/2017
3	Peptides (Polypeptides)IBA 01/2021 - 08/2013
3	Netrin-1IBA 12/2020 - 05/2012
3	Aspartate Aminotransferases (Aspartate Transaminase)IBA 05/2020 - 05/2016
3	Alanine Transaminase (SGPT)IBA 05/2020 - 05/2016
3	salicylhydroxamic acid (SHAM)IBA 01/2019 - 01/2012
3	naringeninIBA 05/2018 - 01/2006
3	CatalaseIBA 05/2017 - 05/2016
2	Therapeutic UsesIBA 09/2022 - 10/2021
2	3-methylquercetinIBA 06/2022 - 12/2019
2	Acetylcarnitine (Alcar)IBA 06/2022 - 05/2017
2	Acetaminophen (Paracetamol)FDA LinkGeneric 06/2022 - 06/2022
2	Myelin Basic ProteinIBA 04/2022 - 01/2013
2	SilverIBA 10/2021 - 01/2018
2	Luxol Fast Blue MBS (Luxol fast blue)IBA 10/2021 - 01/2018
2	Arginine (L-Arginine)FDA Link 01/2021 - 05/2011
2	Sirtuin 3IBA 01/2021 - 10/2019
2	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2021 - 05/2017
2	GalactosamineIBA 01/2021 - 05/2020
2	LinagliptinIBA 01/2021 - 12/2020
2	Proteins (Proteins, Gene)FDA Link 11/2020 - 12/2017
2	Blood Glucose (Blood Sugar)IBA 11/2020 - 12/2019
2	Alkaline PhosphataseIBA 05/2020 - 05/2016
2	EnzymesIBA 05/2020 - 08/2010
2	Superoxide DismutaseIBA 05/2020 - 08/2010
2	N-Methyl-3,4-methylenedioxyamphetamine (MDMA)IBA 01/2020 - 12/2017
2	GhrelinIBA 01/2020 - 12/2017
2	troxerutinIBA 10/2019 - 04/2017
2	Testosterone (Sustanon)FDA Link 05/2019 - 10/2018
2	Glucose (Dextrose)FDA LinkGeneric 05/2019 - 10/2018
2	trigonellineIBA 01/2019 - 08/2018
2	AlkaloidsIBA 01/2019 - 01/2019
2	Coffee FDA Link 01/2019 - 12/2004
2	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2019 - 12/2017

Therapy/Procedure

8	Therapeutics 01/2021 - 07/2010